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The Best Cannabis Strains for Migraines

Migraine headaches affect one billion people around the world each year, but research shows that cannabis could help. After identifying and eliminating any triggers that tend to set off a migraine headache, try these cannabis strains for some welcome relief.

High-CBD Strains for Migraines

High-CBD marijuana strains are ideal for migraine patients who are new to cannabis, who aren't necessarily in it for the high, or who suffer from seizures or anxiety, seeing as THC can cause anxiety at high doses. Instead, the cannabidiol in these strains offers soothing, calming effects in synergy with terpenes and a tiny bit of THC.


Migraine sufferers who are new to cannabis will love this sativa-dominant strain. With a 20:1 ratio of CBD to THC, it's the perfect introduction for patients who want to try the cannabis migraine treatment route without experiencing psychoactive effects. Rich in terpenes myrcene and beta-caryophyllene and boasting CBD levels of up to 19%, ACDC is popular with patients who struggle with inflammation, depression, and anxiety. Expect earthy, sweet aromas and a calm, happy feeling after consuming this strain.


Another high-CBD strain, Harlequin is a sativa-dominant hybrid that is popular for treating migraines and chronic pain. With a pleasant 2:1 ratio of CBD to THC and terpenes myrcene, beta-caryophyllene, and pinene, Harlequin offers a mellow high that still leaves you clear-headed, while easing pain and discomfort. Take this at the first sign of migraine symptoms and enjoy the flavor of earthy mango.


Remedy is similar to ACDC in that it's a CBD-rich cannabis strain with very little THC. This indica generally contains 15% CBD and 1% THC, along with the relaxation-promoting terpenes myrcene and pinene. Remedy is known for its anti-inflammatory and pain-relieving properties, which makes it popular with migraine patients. After consumption, expect feelings of calm and a mellow, relaxing high. Because of the low THC content, this cannabis strain can be consumed at any time of day.

High-THC Strains

If you want something more psychoactive, these are some of the best cannabis strains for migraines. Patients with a severe chronic condition like PTSD or wasting syndrome (both of which are AZ qualifying conditions) may find these high-THC strains especially beneficial.

Purple Kush

A pure indica, Purple Kush offers the ideal combination of pain relief and sleep. This strain has around 0.1% CBD and 17% THC, so the relief from migraine headaches comes mostly from the THC and generous amounts of the relaxing terpenes myrcene and linalool. If you feel migraine symptoms coming on, have some Purple Kush and head to bed. After a euphoric head high, a long-lasting numbing sensation kicks in, helping you relax and sleep until the migraine pain has eased.

Blue Dream

Blue Dream is a west-coast favorite but you can find it in most dispensaries nationwide. There's a good reason this sativa-dominant hybrid is so popular: It is probably one of the most balanced strains out there for migraine sufferers. After breathing in the delectable flavor of sweet blueberry pie, expect a mental uplift and physical relief without any strong sedative effects. This strain has around 17-24% THC with 2% CBD and 1% CBN.

OG Kush

OG Kush is one of the best cannabis strains for migraines and is widely available in dispensaries in the USA. This hybrid strain is pretty powerful with 20% THC, so new patients should go light on this one the first few times. However, the THC combined with CBD and terpenes myrcene, limonene, pinene, and humulene are said to really help with pain relief. In terms of the high, OG Kush is uplifting at first, then makes you feel relaxed and sleepy. Consume before the migraine pain reaches its peak.

White Widow

White Widow is a great option for those who want to treat migraines and feel uplifted and happy at the same time. Originally from Amsterdam, this sativa hybrid comes with THC levels between 18% and 25% along with 1% CBD and 1% CBN and is popular for its mood-boosting and muscle-relaxing effects. White Widow is a great option for migraine relief during the day as it won’t make you feel lethargic or put you to sleep.

How Does Cannabis Help with Migraine Symptoms?

Initially, the effectiveness of cannabis for migraine pain was mainly supported by anecdotal reports. However, a review from the University of Arizona indicates that medical marijuana can help with migraines in several key ways:

  • Shortens the duration of migraines

  • Reduces the number of migraines per month

  • Reduces nausea and vomiting associated with migraines

If you decide to try cannabis for migraines, look for strains that are high in myrcene, pinene, and caryophyllene, all of which are known for their pain-relieving or anti-inflammatory properties [1, 2, 3]. In addition, choose strains with cannabinoid profiles that are appropriate for any other health conditions you might have, such as high-CBD strains for seizures and anxiety, or high-THC strains for PTSD and appetite loss.

The Best Cannabis Strains for Migraines Can Help You Take Back Your Life

A painful migraine can wipe you out for hours and even days, but—according to the experiences of thousands of migraine sufferers—cannabis can provide some much-needed relief.

If you have an MMJ qualifying condition in Arizona, you can schedule a telemedicine medical marijuana appointment with Green Leaf and gain access to more affordable cannabis. And if the first strain you try isn't ideal, don't give up. Everyone responds differently, and you should soon find a strain that provides the relief you need.


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